Thalidomide-induced limb defects: resolving a 50-year-old puzzle
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چکیده
منابع مشابه
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Thalidomide is a potent teratogen that induces a range of birth defects, most commonly of the developing limbs. The mechanisms underpinning the teratogenic effects of thalidomide are unclear. Here we demonstrate that loss of immature blood vessels is the primary cause of thalidomide-induced teratogenesis and provide an explanation for its action at the cell biological level. Antiangiogenic but ...
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ژورنال
عنوان ژورنال: BioEssays
سال: 2009
ISSN: 0265-9247,1521-1878
DOI: 10.1002/bies.200900103